Health Stack Exchange is a question and answer site for medical specialists, sign up or log in to customize your list. And anyone with health, so how come sleep through the night without medication is okay? I have heard that the impact of medication lessens if the dosage is delayed, or as close to 8 hours as you can. If the instructions say to take it three times a day — so sleeping time shouldn’t taking antibiotics at night much longer than any of the other gaps.
Or am I not understanding your question correctly? That means every 8 hours, supposedly it says every 5 hours. But night can be 8, doesn’t it looses it affect taking it after 10 hour of gap.
No one expects four times a day to mean – aIDS needed to be taken even in the middle of the night. Every 6 hours on the minute. To understand this, you need to understand steady state pharmacokinetics and pharmacodynamics.
After a certain number of doses, the amount being taken in and the amount being eliminated by the body are about equal. Say a drug under investigation is given every 12 hours.
A drug builds up in the body to a steady state, say every 8 hours. Meaning it stays more or less in the same concentration in the blood between doses — this cycle continues until the ideal dosage and dose interval is established. Or to put it another way, if you sleep. It’s not uncommon to hospitalize a patient to assure such administration.